MacLean JA

No ORCID on file · 4 papers in corpus · active 2020-2026

Study types

  • other 3
  • article 1

Condition tags

  • endometriosis 4
  • chronic_pelvic_pain 3
  • infertility 1
  • endometrioma 1
other 2026
Repeatedly occurring retrograde menstruation intensifies central sensitization driven by neuroinflammation in endometriosis models
The Journal of clinical investigation ·doi:10.1172/JCI194136

This study investigated how chronic pelvic pain (CPP) develops using rhesus macaques with naturally occurring endometriosis and a multiple lesion induction mouse model (MIM), as repeated retrograde menstruation is considered an underlying m…

other 2025
Multiple lesion inductions intensify central sensitization driven by neuroinflammation in a mouse model of endometriosis
bioRxiv : the preprint server for biology ·doi:10.1101/2025.01.23.634555

INTRODUCTION: Endometriosis is an inflammatory disease associated with chronic pelvic pain (CPP). Growing evidence indicates that endometriotic lesions are not the sole source of pain. Instead, central nervous system (CNS) dysfunction creat…

other 2023
High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia
bioRxiv : the preprint server for biology ·doi:10.1101/2023.11.09.566474

Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation…

article 2020
Niclosamide suppresses macrophage-induced inflammation in endometriosis†
Biology of reproduction ·doi:10.1093/biolre/ioaa010

Endometriosis is a common gynecological disease, which causes chronic pelvic pain and infertility in women of reproductive age. Due to limited efficacy of current treatment options, a critical need exists to develop new and effective treatm…