Gimotty PA

No ORCID on file · 2 papers in corpus · active 2012-2019
2019
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
Science (New York, N.Y.) ·doi:10.1126/science.aaw3145

Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown. To study the role of glycan changes in pancreatic disease, we inducibly expr…

2012
Genetic and pharmacologic inhibition of complement impairs endothelial cell function and ablates ovarian cancer neovascularization.
Neoplasia (New York, N.Y.) ·doi:10.1593/neo.121262

Complement activation plays a critical role in controlling inflammatory responses. To assess the role of complement during ovarian cancer progression, we crossed two strains of mice with genetic complement deficiencies with transgenic mice …