Wood Yee Chan — Endo Lab

article 1984

Differential effects of ibuprofen and naproxen sodium on menstrual prostaglandin release and on prostaglandin production in the rat uterine homogenate

·doi:10.1016/0262-1746(84)90002-7

In two independent studies, ibuprofen and naproxen sodium were found to be equi-effective in alleviating dysmenorrheic symptoms. However, the effects of these drugs on menstrual PG release were found to be dissimilar. Ibuprofen primarily in…

article 1983

Effects of naproxen sodium on menstrual prostaglandins and primary dysmenorrhea.

Prostaglandins E2 and F2 alpha in the menstrual fluid from 12 patients with primary dysmenorrhea were measured by radioimmunoassay (RIA). Each patient was studied for 3 cycles, using vaginal tampons issued for this study. All tampons were c…

review 1983

Prostaglandins and Nonsteroidal Antiinflammatory Drugs in Dysmenorrhea

·doi:10.1146/annurev.pa.23.040183.001023

Due to the massive data sets available for drug candidates, modern drug discovery has advanced to the big data era. Central to this shift is the development of artificial intelligence approaches to implementing innovative modeling based on …

article 1981

Prostaglandins in primary dysmenorrhea

·doi:10.1016/0002-9343(81)90576-3

Prostaglandin synthetase inhibitors have been used in clinical trials for the treatment of primary dysmenorrhea on the theory that the disorder may be caused by a high level of prostaglandins. However, a causal role of prostaglandin in dysm…

article 1979

Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: Effect on prostaglandin levels in menstrual fluid

·doi:10.1016/s0002-9378(79)80026-5

The prostaglandin synthetase inhibitor ibuprofen was evaluated for relief of severe primary dysmenorrhea in a controlled, double-blind, cross-over study in seven patients for a total of 23 menstrual cycles. In eight untreated cycles, the am…