Wang J

Polygonatum odoratum (Mill.) Druce (Angular Solomon's seal) is a medicinal and edible plant belonging to the Asparagaceae family. Phytochemical investigations have revealed its diverse chemical constituents. This review systematically summa…

OBJECTIVE: To evaluate the predictive value of deep myometrial invasion (DMI) for lymph node metastasis (LNM) in low-grade endometrioid carcinoma (LGEC) and its implications for surgical decision-making. METHODS: A retrospective cohort stu…

OBJECTIVE: To investigate the predictive value of preoperative serum markers centered on human epididymis protein 4 (HE4) combined with carbohydrate antigen 125 (CA125) for the risk of suboptimal cytoreduction in advanced epithelial ovarian…

BACKGROUND: Hyperthyroidism adversely impacts female reproduction, yet its association with in vitro fertilization (IVF) outcomes remains controversial. It remains unknown whether ovarian function recovers upon achieving euthyroidism. We co…

Pain assessment is fundamental in pain medicine, anesthesiology, perioperative care, and clinical trials, yet it remains difficult to standardize across diseases, populations, and care settings. This review organizes pain assessment into fo…

OBJECTIVES: The objective of this study was to evaluate the safety and efficacy of intratumoral ethanol injection followed by high-intensity focused ultrasound (HIFU) for hyperintense uterine fibroids on T2-weighted magnetic resonance image…

BACKGROUND: Endometriosis (EMS) and inflammatory bowel disease (IBD) are both chronic inflammatory disorders with overlapping clinical features, suggesting a potentially shared etiology. Although epidemiological studies have reported an ass…

From a pathophysiological standpoint, adolescence is the critical period for the establishment, stabilization, and maturation of the hypothalamic-pituitary-ovarian (HPO) axis. In the 1-2 years following menarche, coinciding with the establi…

Sleep disorders and deficiencies can up-regulate pro-inflammatory mediators, but their potential adverse impact on ovarian function remains not fully understood. In this study, we investigated the immunoregulatory mechanisms underlying slee…

BACKGROUND: Endometriosis (EM) is a disease related to reproductive dysfunction. The mechanism of epigenetic factors (EF) in EM still needs to be studied. Emerging evidence suggests that EF plays a role in the development of EM. However, th…

Ovarian cancer (OC) is a leading cause of gynecologic cancer mortality, with survival prediction limited by existing prognostic models that fail to capture tumor heterogeneity. Conventional methods lack precision for individualized risk ass…

BACKGROUND: The key biomarkers, therapeutic targets, and pathological mechanisms of endometriosis are urgently needed to be elucidated. The role of CTSZ in EM needs to be clarified, and the potential regulatory mechanisms and corresponding …

Neurogenic bladder (NB)-induced fibrosis is the major cause of irreversible bladder dysfunction, yet the underlying mechanisms remain undefined. Here, leveraging single-cell RNA sequencing, the fibrotic landscape of NB is delineated and a d…

Endometriosis is a prevalent gynecologic disorder that significantly impacts women's health. However, its underlying pathogenesis remains unknown. This study aimed to ascertain causal associations between plasma protein levels and endometri…

BACKGROUND AND AIMS: Menstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, an…

Acute pancreatitis is a complex inflammatory disease with high morbidity and mortality, closely associated with intestinal barrier dysfunction, gut microbiota dysbiosis and abnormal lipid metabolism. Akkermansia muciniphila has been shown t…

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that has garnered significant attention due to its potential multiple antitumor mechanisms. This review first explores the current statuses and challenges faced in tumor preventi…

BACKGROUND: Gynecological diseases, such as polycystic ovary syndrome (PCOS) and endometriosis, are prevalent global health concerns. Conventional diagnostics often rely on invasive procedures or costly imaging, limiting accessibility in re…

Filamentous fungi exhibit high heavy metal resistance; elucidating their resistance mechanisms is of practical importance for fungal utilization and for engineering other microorganisms. However, the molecular basis of copper tolerance in f…

Polycystic ovary syndrome (PCOS) affects 11%-13% of reproductive-age women worldwide and is pathologically associated with granulosa cell dysfunction. This study employed transcriptome sequencing of granulosa cells from PCOS patients and no…

BACKGROUND: The SRU consensus on pelvic ultrasound proposed standardized augmented ultrasound, but its validity and indirect signs' role require validation. This study will explore the application value of this consensus in deep endometrios…

ObjectiveTo evaluate whether vitamin D supplementation improves live birth rates in women with polycystic ovary syndrome undergoing in vitro fertilisation.DesignMulticentre, double blind, placebo controlled, randomised clinical trial.Settin…

IntroductionTranscription factor EB (TFEB) deficiency contributes to insufficient autophagic degradation, resulting in zymogen granule (ZG) accumulation and subsequent premature activation, which underlies the pathogenesis of alcoholic panc…

Angiogenesis plays a critical role in the progression of endometriosis, with enhanced glycolysis accelerating pathological angiogenesis. Prior research has identified a central role for N6-methyladenosine (m6A) modification in regulating gl…

Infertility remains a global challenge, with female factors accounting for the majority of cases. Endometrial receptivity (ER), the ability of the endometrium to accept and support embryo implantation, is a critical determinant of successfu…