Oskari Heikinheimo

article 2009

Radical excision of rectovaginal endometriosis results in high rate of pain relief – results of a long‐term follow‐up study

Acta obstetricia et gynecologica Scandinavica ·doi:10.3109/00016340903362558

OBJECTIVE: To evaluate the long-term results of radical excision for rectovaginal endometriosis (RVE) with special emphasis on current symptoms and risk factors as regards recurrence. METHODS: A total of 116 patients operated upon because o…

article 2009

Rectovaginal Endometriosis–Characteristics of Operative Treatment and Factors Predicting Bowel Resection

Journal of Minimally Invasive Gynecology ·doi:10.1016/j.jmig.2008.12.019

Study objectiveThe purpose of this study was to characterize operative treatment of patients with rectovaginal endometriosis (RVE), with special emphasis on factors predicting bowel resection.DesignA total of 153 symptomatic cases undergoin…

article 2007

Intrauterine release of progesterone antagonist ZK230211 is feasible and results in novel endometrial effects: a pilot study

·doi:10.1093/humrep/dem235

BACKGROUND: Continuous administration of progesterone antagonists (PAs) results in endometrial suppression and amenorrhoea in several model systems. We compared the effects of intrauterine release of a highly specific PA, ZK230211, to those…

article 2007

Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium

·doi:10.1093/molehr/gam021

In women, a single dose of the antiprogestin mifepristone (RU486) in the secretory phase rapidly renders the endometrium unreceptive and is followed by endometrial breakdown and menstruation within 72 h. This model provides a system to iden…

article 1996

Inhibition of ovulation by progestin analogs (agonists vs antagonists): Preliminary evidence for different sites and mechanisms of actions

·doi:10.1016/0010-7824(95)00255-3

Continuous administration of the antiprogesterone RU486 inhibits ovulation in women and in monkeys; in this regard RU486 may act as a progestin agonist rather than as an antagonist. We compared the site(s) and mechanism(s) of RU486-induced …

article 1996

Pharmacokinetics of mifepristone after low oral doses

·doi:10.1016/s0010-7824(96)00193-x

Relatively low doses of the antiprogestin mifepristone (RU 486) have recently proven to be efficient for a variety of possible clinical uses of the drug. However, the pharmacokinetics after low single oral doses have not been characterized.…

article 1993

Dose-Response Relationships of RU 486

·doi:10.3109/07853899309147861

Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects. Examples of the dose-dependent effects include the antiglucocorticoid effects of RU 486, whereas pregnancy termina…

article 1988

Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486.

Healthy, regularly menstruating women were treated with the antiprogesterone RU 486, Mifepristone (Roussel-Uclaf, Romainville, France) during the follicular phase of the cycle. Three women were given 25 mg of RU 486 on days 1 to 14 of the c…