Jiang L

RESEARCH QUESTION: Embryo quality serves as a pivotal determinant in assisted reproductive technology (ART) outcomes, with high-grade embryos correlating with improved pregnancy/live birth rates but poor morphology elevating the risks of im…

OBJECTIVE: To investigate the clinical significance of miR-30d-5p and transforming growth factor-β (TGF-β)/Smad2 pathway expression levels in polycystic ovary syndrome (PCOS) patients. METHODS: A total of 82 PCOS patients undergoing their …

OBJECTIVE: To study whether the impact of serum progesterone level on the day of hCG administration on reproductive outcomes varies across age groups and ovarian stimulation protocols in fresh in fresh in vitro fertilization (IVF) and intra…

BACKGROUND: Endometriosis is a chronic inflammatory disease characterized by immune microenvironment dysregulation, with the IL-33/ST2L signaling axis playing a crucial role in macrophage polarization and disease progression. Despite growin…

Endometriosis is a prevalent gynecological disorder characterized by chronic inflammation. Pyroptosis, a type of programmed proinflammatory cell death, plays a crucial role in various inflammatory diseases. However, its specific mechanism i…

OBJECTIVE: To evaluate the clinical efficacy of the combined technique involving Hem-o-lok clip closure of the uterine artery trunk and uterosacral ligament plication in laparoscopic complex hysterectomy. METHODS: A prospective study inclu…

PURPOSE: Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is an innovative minimally invasive procedure. The study aimed to evaluate whether vNOTES achieves non-inferior results compared to conventional laparoscopy in patien…

Endometriosis (EMs) and depression are both common conditions that have a significant negative impact on quality of life. However, it is still unclear about the relationship between them. The study was designed to investigate the phenotypic…

OBJECTIVE: Recurrent implantation failure (RIF) is a significant challenge in assisted reproductive technology (ART), affecting many women undergoing in vitro fertilization (IVF). This study aims to compare the efficacy of various intrauter…

STUDY QUESTION: What are the impacts of different male infertility factors on embryological, cumulative pregnancy and neonatal outcomes of IVF/ICSI cycles? SUMMARY ANSWER: Some severe male infertility factors, i.e. severe oligoasthenozoosp…

Endometriosis is an estrogen-dependent chronic inflammatory disease which causes dysmenorrhea, chronic pelvic pain, and infertility in women of childbearing age, significantly impacting their quality of life and physical and mental health. …

BACKGROUND: Growing evidence suggests that environmental pollutants exert a detrimental impact on female fertility. Among these pollutants, volatile organic compounds (VOCs), easily encountered in the environment, have garnered significant …

PURPOSE: This study aimed to compare the pregnancy outcomes of letrozole (LE)-induced ovulation and hormone replacement treatment (HRT) in endometrial preparation for frozen embryo transfer (FET) in women with polycystic ovary syndrome (PCO…

Microorganisms play an important role in regulating various biological processes in our bodies. In women, abnormal changes in the reproductive tract microbiome are associated with various gynecological diseases and infertility. Recent studi…

Oxazole, a five-membered aromatic heterocycle featuring a nitrogen and an oxygen atom separated by a carbon atom, and its isomer isoxazole, with directly attached oxygen and nitrogen atoms, have been pivotal in medicinal chemistry. Over the…

BACKGROUND: Endometrial thickness independently predicts pregnancy outcomes in frozen embryo transfer (FET) cycles. Thin endometrium always results in implantation failure and worse obstetric-neonatal outcomes. However, it has not been repo…

BACKGROUND: Gynecological diseases significantly impact the reproductive health in women of childbearing age (WCBA). However, there is currently a lack of analysis on the specific burden and forecast of common gynecological diseases for thi…

Polycystic ovary syndrome (PCOS) is an endocrine metabolic syndrome characterized by ovulation disorders, hyperandrogenemia, and polycystic ovaries, which seriously affect the psychological and physical health of childbearing women. N6-meth…

Cross-disease genome-wide association studies (GWASs) unveil pleiotropic loci, mostly situated within the non-coding genome, each of which exerts pleiotropic effects across multiple diseases. However, the challenge "W-H-W" (namely, whether,…

PURPOSE: To summarize the findings of relevant randomized controlled trials (RCTs) and conduct a meta-analysis to investigate the potential effect of aromatase inhibitors on preventing moderate to severe ovarian hyperstimulation syndrome (O…

AIMS: This study aims to explore the alterations of dendritic cells (DCs) subpopulations in ectopic endometrial lesions and unveil the underlying mechanisms. MATERIALS AND METHODS: Patients with endometriosis (n = 81) and women without end…

PURPOSE: To identify the learning curve in ovarian cystectomy by vaginal natural orifice transluminal endoscopic surgery. METHODS: Data consist of consecutively ordered patients who underwent ovarian cystectomy via vaginal natural orifice …

OBJECTIVE: To investigate whether using Zishen Yutai Pills (ZYP) following embryo transfer would affect the live birth rate in frozen-thawed embryo transfer (FET) cycles. METHODS: A retrospective analysis was performed on 15044 FET cycles …

Endometriosis (EMS) is a common gynecological condition with apparent heterogeneity, lack of diagnostic markers, and unclear pathogenesis. A series of bioinformatics methods were employed to explore EMS's pathological mechanisms and potenti…