Setchell KD

ORCID: 0000-0001-9147-0136 · 4 papers in corpus · active 2009-2011
2011
Impact of perinatal exposure to equol enantiomers on reproductive development in rodents.
Reproductive toxicology (Elmsford, N.Y.) ·doi:10.1016/j.reprotox.2011.05.008

There is now considerable interest in the intestinally derived soy isoflavone metabolite, equol, which occurs in the enantiomeric forms, S-(-)equol and R-(+)equol, both differing in biological actions. Little is known about effects of eithe…

2010
Equol: history, chemistry, and formation.
The Journal of nutrition ·doi:10.3945/jn.109.119776

Equol, first isolated from equine urine in 1932 and identified 50 years later in human urine as a metabolite of the soy isoflavones, daidzin and daidzein, is produced by intestinal bacteria in some, but not all, adults. This observation led…

2010
The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer.
Carcinogenesis ·doi:10.1093/carcin/bgq025

We describe for the first time the chemopreventive effects of S-(-)equol and R-(+)equol, diastereoisomers with contrasting affinities for estrogen receptors (ERs). S-(-)equol, a ligand for ERbeta, is an intestinally derived metabolite forme…

2009
The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers.
The American journal of clinical nutrition ·doi:10.3945/ajcn.2009.27981

BackgroundThe nonsteroidal estrogen equol occurs as diastereoisomers, S-(-)equol and R-(+)equol, both of which have significant biological actions. S-(-)equol, the naturally occurring enantiomer produced by 20-30% of adults consuming soy fo…