Huihui Xu

No ORCID on file · 10 papers in corpus
observational 2026
Frontiers in endocrinology ·doi:10.3389/fendo.2026.1811641

BACKGROUND: Pericentric inversion of chromosome 9 [inv (9)] is a common chromosomal polymorphism found in approximately 1-2% of the population. While inv(9) has been generally considered a benign variant, its potential effects on reproducti…

other 2026
International journal of women's health ·doi:10.2147/ijwh.s583951

OBJECTIVE: The study systematically examines the long-term trends in the global burden of Polycystic ovary syndrome (PCOS) across 204 countries and territories, with a specific focus on comparing pre-pandemic (1990-2019) and post-pandemic (…

observational 2026
Journal of ovarian research ·doi:10.1186/s13048-026-02042-9

BACKGROUND: Insulin resistance (IR) is a key metabolic disturbance that adversely affects assisted reproductive technology (ART) outcomes. In women with polycystic ovary syndrome (PCOS), IR has been well documented to impair oocyte quality,…

other 2025
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-024-01341-4

BACKGROUND: Preimplantation embryos in vivo are exposed to various growth factors in the female reproductive tract that are absent in in vitro embryo culture media. Cell-free fat extract exerts antioxidant, anti-ageing, and ovarian function…

observational 2024
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-024-01243-5

BACKGROUND: Among the POSEIDON criteria, group 3 and group 4 have an expected low prognosis. For those patients with inadequate ovary reserve, embryo accumulated from consecutive oocyte retrieval cycles for multiple frozen-thawed embryo tra…

observational 2023
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1093954

BACKGROUND: The basal follicle stimulating hormone (FSH)/luteinizing hormone (LH) ratio is a useful predictor of ovarian response. In this study, we investigated whether the FSH/LH ratios during the entire controlled ovarian stimulation (CO…

other 2021
Journal of Advanced Research ·doi:10.1016/j.jare.2020.09.002

INTRODUCTION: Recurrent implantation failure (RIF) is a challenging problem of assisted reproductive technology that arises mainly due to inadequate endometrial receptivity and its pathogenesis is still unclear. OBJECTIVES: In this study, …

observational 2021
Frontiers in endocrinology ·doi:10.3389/fendo.2021.758896

OBJECTIVE: To evaluate the efficiency and validity of cessation of cetrorelix on trigger day during gonadotropin releasing hormone antagonist (GnRH-ant)-controlled ovarian stimulation of in vitro fertilization (IVF) cycles. METHODS: In thi…

lab-animal 2021
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-021-00823-z

BACKGROUND: Granulosa cells (GCs) in cumulus oophorus highly express follicle stimulating hormone receptor (FSHR), which is the most important mediator of both estradiol synthesis and oocyte maturation. Obese women have elevated free fatty …

observational 2018
Frontiers in endocrinology ·doi:10.3389/fendo.2018.00767

Gonadotropin-releasing hormone antagonist (GnRH-ant) has been shown to negatively influence endometrial receptivity. Reducing the GnRH-ant dose during controlled ovarian stimulation (COS) when using a GnRH-ant protocol may be beneficial to …