Toshimasa Yamauchi

ORCID: 0000-0003-4827-6404 · 3 papers in corpus
2023
A monoclonal antibody activating AdipoR for type 2 diabetes and nonalcoholic steatohepatitis.
Science advances ·doi:10.1126/sciadv.adg4216

Adiponectin receptors, AdipoR1 and AdipoR2 are promising targets for the prevention and treatment of metabolic diseases. In this study, we aimed to establish agonistic antibodies against AdipoR1 and AdipoR2 with a long enough half-life to p…

2020
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.
Nature genetics ·doi:10.1038/s41588-020-0640-3

The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) with 212,453 Japanese individuals …

article 2006
Expression of Adiponectin Receptors and Its Possible Implication in the Human Endometrium
Endocrinology ·doi:10.1210/en.2005-1510

Adiponectin, a pleiotropic cytokine, exerts its effects via the specific receptors AdipoR1 and AdipoR2. Whereas circulating adiponectin concentrations decrease in women with endometriosis and endometrial cancer, possible effects of adiponec…