van Duijn CM — Endo Lab

2016

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Nature genetics ·doi:10.1038/ng.3698

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, …

2016

Genome-wide associations for birth weight and correlations with adult disease.

Nature ·doi:10.1038/nature19806

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular dis…

2015

New genetic loci link adipose and insulin biology to body fat distribution.

Nature ·doi:10.1038/nature14132

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links…

2008

A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions.

American journal of human genetics ·doi:10.1016/j.ajhg.2007.12.020

Predictive genomic profiling used to produce personalized nutrition and other lifestyle health recommendations is currently offered directly to consumers. By examining previous meta-analyses and HuGE reviews, we assessed the scientific evid…