Luis A. Díaz — Endo Lab

2018

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers.

Science translational medicine ·doi:10.1126/scitranslmed.aap8793

We report the detection of endometrial and ovarian cancers based on genetic analyses of DNA recovered from the fluids obtained during a routine Papanicolaou (Pap) test. The new test, called PapSEEK, incorporates assays for mutations in 18 g…

article 2017

Cancer-Associated Mutations in Endometriosis without Cancer

New England Journal of Medicine ·doi:10.1056/nejmoa1614814

BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benig…

2013

Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers.

Science translational medicine ·doi:10.1126/scitranslmed.3004952

Papanicolaou (Pap) smears have revolutionized the management of patients with cervical cancers by permitting the detection of early, surgically curable tumors and their precursors. In recent years, the traditional Pap smear has been replace…

2010

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Science (New York, N.Y.) ·doi:10.1126/science.1196333

Ovarian clear cell carcinoma (OCCC) is an aggressive human cancer that is generally resistant to therapy. To explore the genetic origin of OCCC, we determined the exomic sequences of eight tumors after immunoaffinity purification of cancer …