David J. McLernon

STUDY QUESTION: Can a model be developed to predict natural conception leading to live birth over a period of 12 months in couples with different causes of infertility? SUMMARY ANSWER: We developed and validated a novel clinical prediction…

Study questionAre perinatal outcomes following fresh blastocyst versus fresh cleavage stage embryo transfer (ET) different in singletons, twins, and between singleton siblings?Summary answerSingleton babies conceived following fresh blastoc…

Study questionHow should recurrent implantation failure (RIF) in patients undergoing ART be defined and managed?Summary answerThis is the first ESHRE good practice recommendations paper providing a definition for RIF together with recommend…

Study questionCan two prediction models developed using data from 1999 to 2009 accurately predict the cumulative probability of live birth per woman over multiple complete cycles of IVF in an updated UK cohort?Summary answerAfter being upda…

Study questionCan we develop an IVF prediction model to estimate individualized chances of a live birth over multiple complete cycles of IVF in couples embarking on their second complete cycle of treatment?Summary answerYes, our prediction …

The treatment of unexplained infertility is a contentious topic that continues to attract a great deal of interest amongst clinicians, patients and policy makers. The inability to identify an underlying pathology makes it difficult to devis…

Study questionCan we use prediction modelling to estimate the impact of coronavirus disease 2019 (COVID 19) related delay in starting IVF or ICSI in different groups of women?Summary answerYes, using a combination of three different models …

STUDY QUESTION: Which couples with unexplained subfertility can expect increased chances of ongoing pregnancy with IVF compared to expectant management? SUMMARY ANSWER: For couples in which the woman is under 40 years of age, IVF is associa…

STUDY QUESTION: How well does a previously developed dynamic prediction model perform in an external, geographical validation in terms of predicting the chances of natural conception at various points in time? SUMMARY ANSWER: The dynamic pr…

Objective To develop a prediction model to estimate the chances of a live birth over multiple complete cycles of in vitro fertilisation (IVF) based on a couple's specific characteristics and treatment information.Design Population based coh…