Lindsey A. Sjaarda

Study questionAre insufficient 25-hydroxyvitamin D (25(OH)D) concentrations, and other markers of vitamin D metabolism, associated with premenstrual symptoms in healthy women with regular menstrual cycles?Summary answer25(OH)D insufficiency…

Study questionIs preconception leukocyte telomere length associated with fecundability, pregnancy loss and live birth among women attempting natural conception with a history of 1-2 prior pregnancy losses?Summary answerPreconception leukocy…

OBJECTIVE: To characterize variation in circulating vascular endothelial growth factor (VEGF) and its receptor, soluble fms-like tyrosine kinase-1 (sFLT-1), across the menstrual cycle in normal ovulating women in relation to reproductive ho…

ObjectiveTo estimate the effect of daily 81 mg low-dose aspirin (LDA) on menstrual cycle length and hormone profiles.DesignSecondary analysis of a trial evaluating the effect of daily LDA or placebo on live birth among women with one or two…

ObjectiveTo assess systemic inflammation in relation to fecundability and anovulation.DesignProspective cohort study among participants in the Effects of Aspirin in Gestation and Reproduction trial who were assigned to the placebo.SettingAc…

BackgroundLittle is known about the associations of bisphenol A, chlorophenols, benzophenones, and parabens with reproductive hormone levels in women. Our goal was to evaluate the associations between repeated measures of these chemicals an…

BackgroundPrior studies have reported mixed results regarding relationships between vitamin D, androgens, and sex hormone-binding globulin in patients with polycystic ovary syndrome. However, less is known regarding these associations in eu…

BackgroundDairy food intake has been associated with infertility; however, little is known with regard to associations with reproductive hormones or anovulation.ObjectiveWe investigated whether intakes of dairy foods and specific nutrients …

ContextInflammation is linked to causes of infertility. Low-dose aspirin (LDA) may improve reproductive success in women with chronic, low-grade inflammation.ObjectiveTo investigate the effect of preconception-initiated LDA on pregnancy rat…

BackgroundOvert thyroid dysfunction has been associated with adverse obstetric outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications.ObjectiveThe purp…

ObjectiveTo evaluate if antimüllerian hormone (AMH) is associated with pregnancy loss.DesignProspective cohort study within a block-randomized, double-blind, placebo-controlled trial of low-dose aspirin.SettingNot applicable.Patient(s)Women…

BackgroundEmerging evidence suggests potential links between some dietary fatty acids and improved fertility, because specific fatty acids may affect prostaglandin synthesis and steroidogenesis.ObjectiveThe objective of this exploratory stu…

PurposeThe purpose of this study is to characterize the patterns of medication intake in healthy, reproductive-age women not using hormonal contraception.MethodsTwo hundered fifty-nine healthy, premenopausal women (18-44 years of age) enrol…

BackgroundEvidence is growing that the equilibrium between reactive oxygen species and antioxidants plays a vital role in women's reproductive health.ObjectiveThe objective of this study was to evaluate variations in serum antioxidant conce…

ContextPrior studies examining associations between subclinical hypothyroidism and antithyroid antibodies with early pregnancy loss and live birth suggest mixed results and time to pregnancy (TTP) has not been studied in this patient popula…

Study questionAre prospectively assessed dietary factors, including overall diet quality, macronutrients and micronutrients, associated with luteal phase deficiency (LPD) in healthy reproductive aged women with regular menstrual cycles?Summ…

STUDY QUESTION: Does use of commonly used over-the-counter (OTC) pain medication affect reproductive hormones and ovulatory function in premenopausal women? SUMMARY ANSWER: Few associations were found between analgesic medication use and re…

ObjectiveThe objective of the study was to evaluate whether anti-Müllerian hormone (AMH) is associated with fecundability among women with proven fecundity and a history of pregnancy loss.DesignThis was a prospective cohort study within a m…

Study questionDoes serum anti-Müllerian hormone (AMH) vary significantly throughout both ovulatory and sporadic anovulatory menstrual cycles in healthy premenopausal women?Summary answerSerum AMH levels vary statistically significantly acro…

An evolving body of evidence supports that cadmium, a non-essential heavy metal, may be associated with multiple adverse women's reproductive health outcomes. Our objective was to conduct a systematic review of epidemiologic studies that ev…

PurposeTo determine whether depressive symptoms are associated with ovulation or reproductive hormone concentrations in eumenorrheic women without a reported diagnosis of clinical depression.MethodsA prospective cohort of 248 regularly mens…