Stephen S Palmer

No ORCID on file · 5 papers in corpus
article 2015
Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115600553

Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites. Current endocrine therapies address the estrogenic aspect of disease and offer some relief from pain but are…

article 2015
c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.11.022

ObjectiveTo test the hypothesis that the c-Jun NH2-terminal kinase (JNK) inhibitor (JNKI) bentamapimod (AS602801/PGL5001) can reduce induced endometriosis in baboons.DesignProspective randomized placebo-controlled study.SettingNonhuman prim…

other 2010
A long-acting tumor necrosis factor alpha-binding protein demonstrates activity in both in vitro and in vivo models of endometriosis
The Journal of pharmacology and experimental therapeutics ·doi:10.1124/jpet.110.166488

Endometriosis is characterized by the presence of elevated proinflammatory cytokines such as tumor necrosis factor (TNF) alpha in the peritoneal cavity. Blocking interaction of TNFalpha with its receptor by the addition of excess TNFalpha-b…

article 2010
A Long-Acting Tumor Necrosis Factor -Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models

Endometriosis is characterized by the presence of elevated proinflammatory cytokines such as tumor necrosis factor (TNF) in the peritoneal cavity. Blocking interaction of TNF with its receptor by the addition of excess TNF-binding protein (…

other 2008
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
Molecular pharmacology ·doi:10.1124/mol.107.042176

Tumor necrosis factor (TNF)-alpha is central to the endometriotic disease process. TNF-alpha receptor signaling regulates epithelial cell secretion of inflammation and invasion mediators. Because epithelial cells are a disease-inducing comp…