Li H

BackgroundUterine adenosarcoma is a rare malignant tumor characterized by a biphasic pattern consisting of benign epithelial components and sarcomatous stroma. The subtype with sarcomatous overgrowth is more aggressive and poses significant…

Primary infertility affects 15% of couples worldwide, yet many genetic causes remain unknown. Through whole-exome sequencing of a woman with primary infertility and repeated embryo implantation failure, we identified a novel homozygous fram…

This case report demonstrates the enhanced visualization capabilities of FAPI in visualizing deep infiltrating endometriosis (DIE) lesions compared to ultrasonography and MRI, suggesting its potential as a powerful diagnostic tool in the fu…

Per- and polyfluoroalkyl substances (PFAS) have been previously associated with polycystic ovary syndrome (PCOS). However, the health effects of emerging PFAS alternatives on PCOS remain unclear. This study aims to examine the associations …

The C-reactive protein-triglyceride glucose index (CTI) is a novel marker that integrates systemic inflammation and insulin resistance, both of which are associated with renal injury. However, population-based data on its associations with …

BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) impose significant clinical and economic burdens on healthcare systems globally. Patients in obstetrics and gynecology face unique vulnerabilities; however, population-specif…

OBJECTIVE: High-intensity focused ultrasound (HIFU) therapy is increasingly used in the management of various solid tumors. However, limited data are available regarding the association between HIFU treatment and coagulation function. MATE…

PurposeHaving an Ehlers-Danlos syndrome (EDS) or hypermobility spectrum disorder (HSD) may increase the likelihood of vulvodynia six-fold. Studying vulvodynia in EDS/HSD may help identify causes of vulvodynia and potential treatments. Curre…

Xiaojun Zheng,1,* Yu Wang,1,* Haiping Li,1 Juncha Zhang,1 Jun Liu,1 Xihui Zheng,1 Jie Zhang,1 Guangya Fan,1 Yi Sun,1 Bingxian Li,1 Jingyi Jiao,1 Guang Zuo,1 Xisheng Fan,1,2 Yanfen She1,2 1College of Acupuncture-Moxibustion and Tuina…

PurposeThe objective of this study was to investigate the cumulative pregnancy, cumulative live birth, and perinatal and obstetric outcomes of individuals in the POSEIDON group, with the aim of enhancing the management of individuals receiv…

Acute pancreatitis (AP) is a common, potentially severe inflammatory disease of the pancreas. Although environmental triggers such as alcohol and gallstones are well known, only a subset of exposed individuals develop AP, suggesting that ge…

OBJECTIVES: To compare the differences in clinical characteristics between different types of abdominal wall endometriosis (AWE) according to the invasive levels of tissue mass. METHODS: 122 patients, who had undergone resection of AWE les…

ObjectiveTo evaluate the clinical efficacy of Xiaonang Yusi decoction (XNYSD, ) in patients with phlegm-dampness type polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET), and to investigate its un…

BACKGROUND: Endometriosis (EMS) is a chronic inflammatory disorder involving ectopic endometrial tissue growth. This study investigated IL-33, CD1c+ dendritic cells (DCs) and their co-stimulatory molecules (CD40, CD80, CD86), and IL-17 A in…

Endometriosis diagnosis is often limited by the resolution of conventional imaging techniques (ultrasound/non-targeted MRI) as well as the invasiveness and recurrence risks associated with laparoscopy. To overcome these challenges, we devel…

Vasohibin-1 (VASH-1) is an endothelial protein that serves as a negative feedback regulator of angiogenesis. Through its microtubule carboxypeptidase activity, VASH-1 plays a key role in vascular homeostasis. While previous studies have inv…

Endometrial receptivity is essential for implantation and pregnancy, yet the role of the m6A demethylase FTO remains unclear. We examined epithelial Fto and Wnt signaling during the implantation window using CRISPR/Cas9 Fto knockout mice an…

BackgroundAs the global population ages, pancreatitis in older adults has become a public health issue. Nonetheless, detailed information on its global impact and changing patterns is limited. We sought to explore the epidemiological trends…

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder characterized by ectopic endometrial tissue growth, leading to chronic inflammation and pelvic pain. Despite its high prevalence, the molecular mechanisms underlying EMs rem…

Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo exper…

BackgroundVaricocele represents the most prevalent amendable factor contributing to male infertility. Despite this, considerable debate continues concerning the effectiveness of surgical intervention, especially in terms of enhancing pregna…

ObjectiveBy using the propensity score matching (PSM) method, this study compared the pregnancy outcomes of two ovulation induction regimens, clomiphene citrate (CC) and letrozole (LE), in intrauterine insemination (IUI) cycles. It aimed to…

Unexplained recurrent pregnancy loss (URPL) represents a prevalent obstetric complication and remains a challenging condition with poorly understood genetic etiology. Through whole-exome sequencing of 94 URPL patients, we identified enriche…

Despite the importance of inflammation to menstruation, we lack detailed understanding of how immune dynamics contribute to endometrial repair. We performed detailed phenotypic characterisation of uterine immune cells using single cell RNA …