Badgwell D

No ORCID on file · 4 papers in corpus · active 2007-2011
2011
Proteomic biomarkers apolipoprotein A1, truncated transthyretin and connective tissue activating protein III enhance the sensitivity of CA125 for detecting early stage epithelial ovarian cancer.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2011.06.002

ObjectiveThe low prevalence of ovarian cancer demands both high sensitivity (>75%) and specificity (99.6%) to achieve a positive predictive value of 10% for successful early detection. Utilizing a two stage strategy where serum marker(s) pr…

2009
Urinary levels of Bcl-2 are elevated in ovarian cancer patients.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2008.09.037

Objective(s)The poor prognosis associated with ovarian cancer is due to the lack of overt early symptoms and the absence of reliable diagnostic screening methods. Since many tumors overexpress anti-apoptotic proteins, the purpose of this st…

2007
Early detection of ovarian cancer.
Disease markers ·doi:10.1155/2007/309382

Despite advances in therapy, ovarian cancer remains the most deadly of the gynecological cancers. Less than 30% of women with advanced stage disease survive long-term. When diagnosed in stage I, up to 90% of patients can be cured with conve…

2007
Urinary mesothelin provides greater sensitivity for early stage ovarian cancer than serum mesothelin, urinary hCG free beta subunit and urinary hCG beta core fragment.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2007.04.022

ObjectivesEarly detection of ovarian cancer should improve overall survival. Multiple serum markers have been evaluated as possible tests to detect early stage disease, but few urine markers have been studied. Mesothelin has been detected i…