Hosono K

No ORCID on file · 10 papers in corpus · active 2010-2025

Study types

  • article 6
  • review 1

Condition tags

  • endometriosis 7
article 2025
In vivo (Athens, Greece) ·doi:10.21873/invivo.14059

BACKGROUND/AIM: Endometriosis is characterized by the accumulation of immune cells in endometrial lesions and the peritoneal cavity. Macrophages contribute to the growth and neovascularization of endometriotic lesions. Vascular endothelial …

2024
In vivo (Athens, Greece) ·doi:10.21873/invivo.13422

Background/aimIntestinal lymphatic vessels (lacteals) play a critical role in the absorption and transport of dietary lipids into the circulation. Calcitonin gene-related peptide and receptor activity-modifying protein 1 (RAMP1) are involve…

2024
In vivo (Athens, Greece) ·doi:10.21873/invivo.13691

Background/aimThe liver effectively restores both size and function following partial hepatectomy (PHx). Angiogenesis is crucial for the repair and regeneration of liver tissue post-PHx. Calcitonin gene-related peptide (CGRP) released from …

article 2023
Molecular medicine reports ·doi:10.3892/mmr.2023.13079

Endometriosis is highly dependent on angiogenesis and lymphangiogenesis. Prostaglandin E2, an arachidonic acid metabolite, has been shown to promote the formation of new blood and lymphatic vessels. However, the role of another arachidonic …

review 2022
Pharmacology & therapeutics ·doi:10.1016/j.pharmthera.2021.108011

Lymphatic vessels have crucial roles in the regulation of interstitial fluids, immune surveillance, and the absorption of dietary fat in the intestine. Lymphatic function is also closely related to the pathogenesis of various disease states…

2022
In vivo (Athens, Greece) ·doi:10.21873/invivo.12932

Background/aimMicrosomal prostaglandin E synthase-1 (mPGES-1) is an enzyme, which catalyzes the final step of prostaglandin E2 (PGE2) synthesis. PGE2 in involved in wound-induced angiogenesis. Regulatory T cells (Tregs) regulate not only im…

article 2020
Journal of cellular and molecular medicine ·doi:10.1111/jcmm.15823

Abstract Neuroimmune interactions are involved in the development of endometriosis. Here, we examined the role of a neuropeptide, calcitonin gene–related peptide (CGRP), and its receptor, receptor activity–modifying protein (RAMP) 1, in gro…

article 2020
Journal of pharmacological sciences ·doi:10.1016/j.jphs.2020.05.003

Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis. Endometrial fragments fro…

article 2019
Scientific reports ·doi:10.1038/s41598-019-43185-8

Abstract Angiogenesis is critical in maintenance of endometrial tissues. Here, we examined the role of VEGF receptor 1 (VEGFR1) signaling in angiogenesis and tissue growth in an endometriosis model. Endometrial fragments were implanted into…

article 2010
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie ·doi:10.1016/j.biopha.2010.12.008

Endometriosis is one of the most common gynecological diseases in women of reproductive age. Although cyclooxygenase (COX)-2 inhibitors are effective in the treatment of endometriosis, the adverse cardiovascular effects associated with thes…