Ben Van Calster

ObjectiveTo investigate the accuracy of risk prediction models and scores for diagnosing ovarian cancer in premenopausal women presenting to secondary care with symptoms and abnormal test results.DesignProspective cohort study.SettingSecond…

BackgroundSeveral diagnostic prediction models to help clinicians discriminate between benign and malignant adnexal masses are available. This study is a head-to-head comparison of the performance of the Assessment of Different NEoplasias i…

IntroductionThere is no global agreement on how to best determine pregnancy of unknown location viability and location using biomarkers. Measurements of progesterone and β human chorionic gonadotropin (βhCG) are still used in clinical pract…

STUDY QUESTION: Do sonographic characteristics of ovarian endometriomas vary with age in premenopausal women? SUMMARY ANSWER: With increasing age, multilocular cysts and cysts with papillations and other solid components become more common …

In multicentre studies, measurements will vary between centres for various reasons (e.g. subjectivity of measurements, differences in equipment, deviations from the protocol and differences in patient populations). The aim of this interim a…

To assess ultrasonographic features of adnexal endometriomas in relation to patient age in premenopausal patients. Retrospective cross-sectional analysis of 5914 adnexal masses from the International Ovarian Tumor Analysis (IOTA) study. All…

BACKGROUND: To compare different ultrasound-based international ovarian tumour analysis (IOTA) strategies and risk of malignancy index (RMI) for ovarian cancer diagnosis using a meta-analysis approach of centre-specific data from IOTA3. ME…

We evaluated the implementation of a strict procedure for endometrium biopsy, including pre-sampling ultrasound examination and assessment of the tissue yield during sampling, in 257 consecutive women with abnormal bleeding. The tissue yiel…

OBJECTIVES: To describe the ultrasound characteristics of endometriomas in pre- and postmenopausal patients and to develop rules that characterize endometriomas. METHODS: All patients included in the International Ovarian Tumor Analysis (IO…

AIM: To evaluate the performance of subjective evaluation of ultrasound findings (pattern recognition) to discriminate endometriomas from other types of adnexal masses and to compare the demographic and ultrasound characteristics of the tru…

To define which US characteristics are suggestive for endometriosis and with which ultrasound features “atypical” endometriomas (Eomas) present. The IOTA study included 3513 patients with an adnexal mass. Histologically proven Eomas were in…

UNLABELLED: OBJECTIVE STUDY: To estimate the value of preoperative bimanual examination of the pelvis in women undergoing total laparoscopic hysterectomy (TLH). DESIGN: Prospective observational cohort study. SETTING: Private hospitals an…