Wu X

ObjectivesThe aim of this study was to assess the clinical outcomes of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in patients with breast fibroadenoma (FA) of different sizes.Materials and methodsA total of 88 patients …

PurposeTo evaluate the relationships between the sperm DNA fragmentation index (DFI) and semen parameters and its application in fresh embryos via in vitro fertilization and transfer.MethodsA retrospective propensity score matching (PSM) st…

IntroductionCarnitine palmitoyltransferase 1A (CPT1A) is crucial for mitochondrial function, and its dysfunction has been linked to the development of several diseases. However, the role of CPT1A in severe acute pancreatitis (SAP) and its u…

Endometriosis (EMs) is an estrogen-dependent chronic inflammatory disease. While apoptosis resistance (evidenced by Bcl-2 upregulation and Bax/caspase-3 downregulation) remains a hallmark of EMs, recent studies reveal a paradoxical coexiste…

Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disorder characterized by significant clinical heterogeneity. The etiology of PCOS remains elusive, though it is closely linked to genetic, metabolic, endocrine, and env…

ObjectiveThe aim of this study is to assess the impact of different embryo transfer strategies, focusing on cleavage-stage embryos and blastocysts, on pregnancy and neonatal outcomes in frozen-thawed embryo transfer (FET) cycles among women…

ObjectivesTo evaluate the efficacy and safety of ultrasound-guided percutaneous thermal ablation for abdominal wall metastases.Materials & methodsWe retrospectively analyzed patients with abdominal wall metastatic nodules who underwent ultr…

The unique physiological structure of women has led to a variety of diseases that have attracted the attention of many people in recent years. Disturbances in the reproductive system microenvironment lead to the progression of various femal…

ObjectiveTo compare the outcomes of hysterectomy performed via traditional inpatient procedure versus day-care procedure with a focus on surgical time, post-operative recovery, costs, and patient satisfaction, using propensity score matchin…

OBJECTIVE: To evaluate various body fat indicators under weight management on the time to complete response (CR) in overweight patients undergoing fertility-sparing treatment for endometrial cancer (EC) or atypical hyperplasia (AEH). METHOD…

Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in …

Xian Wu,1,* Xia Yu,2,* Lu Yang,1,* Aijie Xie,1 Yunyi Su,1 Ling Zhang,1 Yonghong Lin,1 Xiaoqin Gan1 1Department of Obstetrics and Gynecology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Elec…

PURPOSE: Ovarian endometriosis, a prevalent condition in reproductive-age women, causes dysmenorrhea and infertility, significantly impairing quality of life. To date, there is no systematic description of ovarian endometriosis in the liter…

Endometriosis (EMs) is a common inflammatory disorder in women of reproductive age, severely impacting patients' quality of life and fertility. Current hormonal therapies offer limited efficacy, and surgical interventions often fail to prev…

BackgroundKuntai capsules, a traditional Chinese medicine, are speculated to improve the treatment outcomes of patients with ovarian reserve dysfunction (DOR), but existing evidence is limited.ObjectiveTo investigate the effects of Kuntai c…

BACKGROUND: Fresh embryo transfer reduces waiting time and minimizes embryo cryodamage for endometriosis (EM) patients. The current prediction models for fresh embryo transfer outcomes in EM primarily rely on logistic regression, with limit…

BackgroundMicroRNAs (miRNAs) exert a crucial role in the progression of lung cancer (LC) and can serve as prognostic biomarkers.AimTo analyze the prognostic value of miR-3613-5p and its regulatory effect on XPO6 in LC, this study was conduc…

Macrophages are vital sentinels in innate immunity, and their functions cannot be performed without internal metabolic reprogramming. Mitochondrial dynamics, especially mitochondrial fusion and fission, contributes to the maintenance of mit…

Background: Pulmonary benign metastasizing leiomyoma (PBML) is a rare condition characterized by histologically benign smooth muscle tumors occurring at extrauterine sites, often in women with a history of uterine leiomyoma. While PBML gene…

Fertility in women decreases with age, but the molecular basis for age-related, unexplained infertility remains elusive. Here, we reveal distinct transcriptome changes in oocytes and surrounding cumulus cells from women in their mid-thirtie…

ObjectiveThis study aims to investigate the risk factors for severe postpartum hemorrhage (SPPH) in patients with placenta accreta spectrum (PAS) undergoing cesarean delivery, despite the prophylactic use of resuscitative endovascular ballo…

Intrauterine adhesions (IUA), characterized by endometrial fibrosis, pose a serious threat to women's reproductive health, yet their molecular mechanisms remain poorly understood. Here, we use single-cell RNA sequencing (scRNA-seq) to profi…

Silent information regulator type 1 (SIRT1), a NAD+-dependent deacetylase, is a central regulator of cancer cell adaptation to oxidative stress and senescence. By deacetylating redox-sensitive transcription factors, such as p53, FOXOs, PGC-…

Ovarian cancer(OC) is the second most common gynecological malignancy worldwide. While traditional treatments such as cytoreductive surgery, chemotherapy, and targeted drugs have made progress, patients with advanced disease still face high…

ObjectiveThis study aims to observe whether right-sided stellate ganglion block (SGB) before surgery can improve early postoperative recovery quality in peri-menopausal women undergoing elective gynecological laparoscopic surgery.MethodsNin…