BackgroundThe cervicovaginal microbiome plays a critical role in women's health with microbial communities dominated by Lactobacillus species considered optimal. In contrast, the depletion of lactobacilli and the presence of a diverse array…
The vaginal microbiota is critical for reproductive health, and its disruption, particularly the loss of Lactobacillus spp. and dominance of anaerobes such as Mobiluncus mulieris (community state type IV, CST IV), is associated with bacteri…
Abstract Introduction Pelvic pain (dysmenorrhea and non-menstrual) is the most common presentation of adolescent endometriosis, but symptoms vary between and within patients. Other presentations, such as gastrointestinal (GI) symptoms, are …
Emily L Leventhal,1,2 Nivedita Nukavarapu,1,2 Noemie Elhadad,3 Suzanne R Bakken,4 Michal A Elovitz,5 Robert P Hirten,1,2,6 Jovita Rodrigues,1,2 Matteo Danieletto,1,2 Kyle Landell,1,2 Ipek Ensari1,2 1Windreich Department of Artificial Intell…
Background: Female chronic pelvic pain disorders (CPPDs) affect 1 in 7 women worldwide and are characterized by psychosocial comorbidities, including a reduced quality of life and 2– 10-fold increased risk of depression and anxiety. Despite…
Colonization of the vaginal space with bacteria such as Gardnerella vaginalis and Mobiluncus mulieris is associated with increased risk for STIs, bacterial vaginosis, and preterm birth, while Lactobacillus crispatus is associated with optim…
Intrauterine fetal demise (IUFD) - fetal loss after 20 weeks - affects 6 pregnancies per 1,000 live births in the United States, and the majority are of unknown etiology. Maternal systemic regulatory T cell (Treg) deficits have been implica…