Londregan A

ORCID: 0000-0002-7622-548X · 2 papers in corpus
2023
Journal of neurochemistry ·doi:10.1111/jnc.16022

While visceral pain is commonly associated with disorders of the gut-brain axis, underlying mechanisms are not fully understood. Dorsal root ganglion (DRG) neurons innervate visceral structures and undergo hypersensitization in inflammatory…

2023
The Journal of clinical investigation ·doi:10.1172/jci165578

Visceral pain (VP) is a global problem with complex etiologies and limited therapeutic options. Guanylyl cyclase C (GUCY2C), an intestinal receptor producing cyclic GMP(cGMP), which regulates luminal fluid secretion, has emerged as a therap…