J. Wade Davis

ORCID: 0000-0002-1111-6848 · 5 papers in corpus
meta-analysis 2022
The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases
BMC medical genomics ·doi:10.1186/s12920-022-01216-w

BACKGROUND: The remarkable growth of genome-wide association studies (GWAS) has created a critical need to experimentally validate the disease-associated variants, 90% of which involve non-coding variants. METHODS: To determine how the fie…

2018
Integrative Analysis of DNA Methylation and RNA-Seq Data for Biomarker Detection of Endometriosis.
2017
A multi-omics informatics approach for identifying molecular mechanisms and biomarkers in clinical patients with endometriosis
·doi:10.1109/bibm.2017.8218003

Endometriosis is a complex gynecological disorder. The diagnostic process of endometriosis involves an invasive procedure thus delaying the diagnosis for about 10 years on average. Both DNA-methylation data and RNA-seq data has the potentia…

lab-animal 2013
Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first-generation and second-generation embryos
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.07.007

OBJECTIVE: To characterize multigenerational gene expression anomalies in eight-cell stage embryos associated with developmental exposure to endometriosis. DESIGN: Using an endometriosis model in rats (F0 founder generation) to evaluate ge…

lab-animal 2009
Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.03.086

OBJECTIVE: To define the altered gene expression profile of endometriotic lesions in a mouse model of surgically induced endometriosis. DESIGN: Autologous experimental mouse model. SETTING: Medical school department. ANIMAL(S): Adult C57…