Hayes TB

No ORCID on file · 4 papers in corpus · active 2006-2013
2013
Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology.
Reproductive toxicology (Elmsford, N.Y.) ·doi:10.1016/j.reprotox.2013.02.002

For years, scientists from various disciplines have studied the effects of endocrine disrupting chemicals (EDCs) on the health and wellbeing of humans and wildlife. Some studies have specifically focused on the effects of low doses, i.e. th…

2012
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.
Endocrine reviews ·doi:10.1210/er.2011-1050

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of "the dose makes the poison," because EDCs can have effects at low doses that are not predicted by e…

2007
Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans.
Environmental health perspectives ·doi:10.1289/ehp.9758

BackgroundAtrazine is a potent endocrine disruptor that increases aromatase expression in some human cancer cell lines. The mechanism involves the inhibition of phosphodiesterase and subsequent elevation of cAMP.MethodsWe compared steroidog…

2006
Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis.
Environmental health perspectives ·doi:10.1289/ehp.8067

Atrazine is a potent endocrine disruptor that both chemically castrates and feminizes male amphibians. It depletes androgens in adult frogs and reduces androgen-dependent growth of the larynx in developing male larvae. It also disrupts norm…