Kazuhiko Imakawa

ORCID: 0000-0002-3798-3560 · 5 papers in corpus
2025
Biological Aging and Uterine Fibrosis in Cattle: Reproductive Trade-Offs from Enhanced Productivity.
Cells ·doi:10.3390/cells14130955

Reproductive efficiency in cattle remains sub-optimal, with pregnancy rates often below 50%, despite fertilization rates approaching 100%, indicating that implantation failure and/or early embryonic loss are major limiting factors. This dis…

article 2015
Regulatory Action of Calcium Ion on Cyclic AMP-Enhanced Expression of Implantation-Related Factors in Human Endometrial Cells
PloS one ·doi:10.1371/journal.pone.0132017

Decidualization of human endometrial stroma and gland development is mediated through cyclic AMP (cAMP), but the role of intracellular calcium ion (Ca2+) on cAMP mediated-signaling in human endometrial stroma and glandular epithelia has not…

article 2013
MOLECULAR REPRODUCTION AND DEVELOPMENT 73:850–858 (2006) Regulation of Conceptus Adhesion by Endometrial CXC Chemokines During the Implantation Period in Sheep

ABSTRACT To gain a better understanding of biochemical mechanisms of conceptus adhesion to the maternal endometrium in ruminant ungulates, the present study was performed to clarify roles of chemokines and extracellular matrix (ECM) compone…

article 2013
Regulation of decidualization in human endometrial stromal cells through exchange protein directly activated by cyclic AMP (Epac)
·doi:10.1016/j.placenta.2012.12.017

IntroductionHuman endometrial stromal cells (ESCs) undergo differentiation during the decidualization process. Decidualization is characterized by their enhanced production of IGF binding protein-1 (IGFBP-1), prolactin (PRL), and the forkhe…

article 2006
Progesterone initiates Wnt-β-catenin signaling but estradiol is required for nuclear activation and synchronous proliferation of rat uterine stromal cells
·doi:10.1677/joe.1.07030

Progesterone pretreatment of ovariectomized rat uteri increases the number of synchronously proliferating stromal cells in response to estradiol 17-beta. To identify the signals involved in stimulating synchronous proliferation, sexually ma…