Waldman SA

ORCID: 0000-0001-6619-175X · 3 papers in corpus
2023
Frontiers in neuroscience ·doi:10.3389/fnins.2023.1272955

Enteroendocrine cells (EECs) are an essential interface between the gut and brain that communicate signals about nutrients, pain, and even information from our microbiome. EECs are hormone-producing cells expressed throughout the gastrointe…

2023
Journal of neurochemistry ·doi:10.1111/jnc.16022

While visceral pain is commonly associated with disorders of the gut-brain axis, underlying mechanisms are not fully understood. Dorsal root ganglion (DRG) neurons innervate visceral structures and undergo hypersensitization in inflammatory…

2023
The Journal of clinical investigation ·doi:10.1172/jci165578

Visceral pain (VP) is a global problem with complex etiologies and limited therapeutic options. Guanylyl cyclase C (GUCY2C), an intestinal receptor producing cyclic GMP(cGMP), which regulates luminal fluid secretion, has emerged as a therap…