Tuveson DA

ORCID: 0000-0002-8017-2712 · 3 papers in corpus
2019
Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1908626116

Pancreatic ductal adenocarcinoma (PDAC) has prominent extracellular matrix (ECM) that compromises treatments yet cannot be nonselectively disrupted without adverse consequences. ECM of PDAC, despite the recognition of its importance, has no…

2019
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
Science (New York, N.Y.) ·doi:10.1126/science.aaw3145

Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown. To study the role of glycan changes in pancreatic disease, we inducibly expr…

2009
Modelling oncogenic Ras/Raf signalling in the mouse.
Current opinion in genetics & development ·doi:10.1016/j.gde.2008.12.006

The Ras/Raf/MEK/ERK (or MAPK) signalling pathway relays extracellular stimuli to the nucleus, thereby regulating diverse cellular responses such as proliferation, growth, differentiation and apoptosis. Perturbation of these processes by abe…