Jongyoon Han

ORCID: 0000-0001-7215-1439 · 3 papers in corpus
lab-animal 2015
High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation
Integrative biology : quantitative biosciences from nano to macro ·doi:10.1039/c5ib00019j

As key components of autocrine signaling, pericellular proteases, a disintegrin and metalloproteinases (ADAMs) in particular, are known to impact the microenvironment of individual cells and have significant implications in various patholog…

lab-animal 2013
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1222387110

A Disintegrin and Metalloproteinases (ADAMs) are the principal enzymes for shedding receptor tyrosine kinase (RTK) ectodomains and ligands from the cell surface. Multiple layers of activity regulation, feedback, and catalytic promiscuity im…

other 2012
Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis
Journal of the American Chemical Society ·doi:10.1021/ja307866z

As principal degrading enzymes of the extracellular matrix, metalloproteinases (MPs) contribute to various pathologies and represent a family of promising drug targets and biomarker candidates. However, multiple proteases and endogenous inh…