Nahed Ismail

ORCID: 0000-0002-2399-7582 · 3 papers in corpus
lab-animal 2023
Epigenetic Modulation of Inflammatory Pathways in Myometrial Stem Cells and Risk of Uterine Fibroids
International journal of molecular sciences ·doi:10.3390/ijms241411641

The period during which tissue and organ development occurs is particularly vulnerable to the influence of environmental exposures. However, the specific mechanisms through which biological pathways are disrupted in response to developmenta…

review 2022
Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders
Frontiers in cellular and infection microbiology ·doi:10.3389/fcimb.2022.1059825

Every year, millions of women are affected by genital tract disorders, such as bacterial vaginosis (BV), endometrial cancer, polycystic ovary syndrome (PCOS), endometriosis, and uterine fibroids (UFs). These disorders pose a significant eco…

lab-animal 2007
Toward gene therapy of endometriosis: adenovirus-mediated delivery of dominant negative estrogen receptor genes inhibits cell proliferation, reduces cytokine production, and induces apoptosis of endometriotic cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.11.046

OBJECTIVE: To use dominant negative mutants of estrogen receptor genes delivered to endometriosis cells via an adenovirus vector (Ad-DN-ER) to abrogate estrogen action on these cells. DESIGN: Experimental in vitro study. SETTING: Universi…