Yana Cen

The human sirtuins (SIRT1-SIRT7) are NAD+-dependent protein deacylases that orchestrate key cellular events such as metabolism, stress response, DNA repair, and aging. Accumulating evidence highlights their central role in women's health. T…

The human sirtuins are a group of NAD+-dependent protein deacylases. They "erase" acyl modifications from lysine residues in various cellular targets including histones, transcription factors, and metabolic enzymes. Through these far-reachi…