Ken K Ong — Endo Lab

2024

Mendelian randomization identifies circulating proteins as biomarkers for age at menarche and age at natural menopause.

Communications biology ·doi:10.1038/s42003-023-05737-7

Age at menarche (AAM) and age at natural menopause (ANM) are highly heritable traits and have been linked to various health outcomes. We aimed to identify circulating proteins associated with altered ANM and AAM using an unbiased two-sample…

other 2023

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Nature human behaviour ·doi:10.1038/s41562-023-01528-6

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci a…

2021

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Nature human behaviour ·doi:10.1038/s41562-021-01135-3

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify…

2018

The association between age at menarche and later risk of gestational diabetes is mediated by insulin resistance.

Acta diabetologica ·doi:10.1007/s00592-018-1162-7

AimsAssociations have been reported between age at menarche and the later risk of gestational diabetes. However, it is not known whether these associations reflect differences in insulin sensitivity and/or pancreatic β-cell function in preg…