OBJECTIVE: To study the relationship between conception by assisted reproductive technology (ART) and risk of endometriosis/adenomyosis in female offspring. DESIGN: National registry-based cohort study. SUBJECTS: We studied 449,611 female…
STUDY QUESTION: Is age at menarche associated with fecundability? SUMMARY ANSWER: Both early (15 years) menarche is associated with decreased fecundability. WHAT IS KNOWN ALREADY: Previous studies on age at menarche and fecundability have b…
Study questionIs the use of ART, a proxy for infertility, associated with epigenetic age acceleration?Summary answerThe epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed significantly between n…
Study questionIs fecundability associated with miscarriage history and future miscarriage risk?Summary answerPrior miscarriage was associated with lower fecundability, and participants with a history of subfertility (time-to-pregnancy (TTP)…
BACKGROUND: Increased risk of miscarriage has been reported for women with specific chronic health conditions. A broader investigation of chronic diseases and miscarriage risk may uncover patterns across categories of illness. The objective…
A few studies indicate that women with prolonged time-to-pregnancy (TTP) have an increased risk of cardiovascular disease (CVD). This has not been studied in men. We evaluated CVD risk by self-reported TTP among parous women (n = 64,064) an…