David J. Orlicky

BACKGROUND: Regenerative remodeling of the pelvic floor after labor and delivery restores pelvic organ positioning. In some individuals, accumulated tissue damage leads to failure of support structures, including the uterosacral ligament (U…

Induction of heme oxygenase-1 (HO-1/ Hmox1 ) is broadly considered cytoprotective, but the role of colonic epithelial HO-1 in colitis-associated tumorigenesis is poorly defined. HO-1 catabolizes heme, releasing ferrous iron, a key driver o…

Trichrome stained uterosacral ligament histological preparations from specimen biorepository. Images in this file were from control patients that lacked a diagnosis of pelvic organ prolapse. Specimens were evaluated using quantitative and s…