John J. Jeffrey

No ORCID on file · 4 papers in corpus · active 1991-2002

Study types

  • article 4
article 2002
Serotonin-induced MMP-13 Production Is Mediated via Phospholipase C, Protein Kinase C, and ERK1/2 in Rat Uterine Smooth Muscle Cells
·doi:10.1074/jbc.m205094200

Serotonin (5-hydroxytryptamine; 5-HT), acting via the 5-HT(2A) receptor, up-regulates the transcription and production of interstitial collagenase (matrix metalloproteinase-13; MMP-13), a critical enzyme responsible for maintaining the inte…

article 1994
Regulation of uterine collagenase gene expression: interactions between serotonin and progesterone
·doi:10.1016/0303-7207(94)90220-8
article 1992
Regulation of collagenase gene expression by serotonin and progesterone in rat uterine smooth muscle cells.
·doi:10.1016/s0021-9258(19)36750-x

The regulation of collagenase gene expression by serotonin and progesterone was investigated in primary cultures of rat uterine smooth muscle cells. Northern blot analysis demonstrates that serotonin (5-hydroxytryptamine (5-HT)), when admin…

article 1991
Serotonin: An inducer of collagenase in myometrial smooth muscle cells
·doi:10.1002/jcp.1041460310

Rat myometrial smooth muscle cells in culture actively produce collagenase in medium containing fetal bovine serum, but not in medium containing newborn bovine serum or containing fetal serum adsorbed with dextran-coated charcoal. A dialyza…