ObjectiveTo compare the effect of luteal-phase progesterone supplementation in natural cycles to expectant management on live birth rates in women with unexplained infertility (UI).DesignAn open-label, parallel-arm, single-centre randomised…
PurposeTo investigate the possibility that altered actions of endogenous progesterone affect receptivity and contribute to unexplained infertility (UI).MethodsTwo authors electronically searched MEDLINE, CINAHL and Embase databases from inc…
Study questionWhat is the recommended management for couples presenting with unexplained infertility (UI), based on the best available evidence in the literature?Summary answerThe evidence-based guideline on UI makes 52 recommendations on t…
Most aspects of in-vitro fertilisation (IVF) have changed dramatically since introduction, but embryo transfer (ET) technique remains largely unaltered. We aimed to determine whether four-dimensional ultrasound guided embryo transfers (4D U…
ObjectiveTo compare success rates, associated risks and cost-effectiveness between intrauterine insemination (IUI) and in vitro fertilisation (IVF).DesignRetrospective observational study.SettingThe UK from 2012 to 2016.ParticipantsData fro…
IUI has been practiced for five decades but only three unconvincing trials attempted to demonstrate the superiority of IUI over sexual intercourse (SI). In the absence of evidence of its effectiveness, the National Institute for Clinical Ex…
This review addresses the misplaced facts about the IUI procedure within a lucrative fertility industry. Evidence suggests IUI must be a first-line treatment option for most couples except in cases of bilateral tubal blockage and severe oli…