Cooney RA

ORCID: 0000-0003-0921-6943 · 1 paper in corpus

2023

Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium.

American journal of physiology. Lung cellular and molecular physiology ·doi:10.1152/ajplung.00382.2022

Multiciliated cell loss is a hallmark of airway epithelial remodeling in chronic inflammatory airway diseases including cystic fibrosis (CF), asthma, and chronic obstructive pulmonary disease. It disrupts mucociliary clearance, which fuels …