Michael Wolfe

No ORCID on file · 1 paper in corpus · active 2022
2022
Effects of Presenilin-1 Familial Alzheimer’s Disease Mutations on γ-Secretase Activation for Cleavage of Amyloid Precursor Protein
·doi:10.21203/rs.3.rs-1910553/v1

Abstract γPresenilin-1 (PS1) is the catalytic subunit of γ-secretase, the “proteasome of the membrane” which cleaves within the membrane of 150 + peptide substrates. Dominant missense mutations in PS1 cause early-onset familial Alzheimer’s…