McHugh PC

ORCID: 0000-0003-0661-919X · 1 paper in corpus

2019

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway.

ACS omega ·doi:10.1021/acsomega.9b01228

Tetrahydrobiopterin (BH4) is a cofactor in the production of various signaling molecules including nitric oxide, dopamine, adrenaline, and noradrenaline. BH4 levels are critical for processes associated with cardiovascular function, inflamm…