Yi Zhun Zhu

ORCID: 0000-0001-7700-8041 · 7 papers in corpus
article 2025
SCM-198 Inhibits EMS Development by Reversing Decreased Proportions of IFN-γ+T Cells and CCR5+T Cells
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-025-01823-9

Endometriosis is a common gynecological disease that causes severe pain and infertility. However, the available treatments for EMS are limited. SCM-198, a synthetic form of leonurine, possesses various abilities, including anti-inflammatory…

article 2024
Cell membrane camouflaged and ROS responsive nanosomes for targeted endometriosis therapy via reversing inflammatory, low-autophagy, and immunotolerant microenvironment
·doi:10.1016/j.cej.2024.152697
article 2023
SCM-198 prevents endometriosis by reversing low autophagy of endometrial stromal cell via balancing ERα and PR signals
·doi:10.1016/j.jri.2023.103861
article 2022
SCM-198 Alleviates Endometriosis by Suppressing Estrogen-ERα mediated Differentiation and Function of CD4+CD25+ Regulatory T Cells
International journal of biological sciences ·doi:10.7150/ijbs.68224

Background: Endometriosis (EMS), a typical endocrine immune disorder, associates with dramatically increased estrogen production and disorganized immune response in ectopic focus. Peritoneal regulatory T cells (Tregs) expansion in women wit…

preprint 2022
SCM-198 Prevents Endometriosis By Reversing Low Autophagy Levels Of Endometriotic Stromal Cells Via Inhibiting TNF-Α-Aromatase-Estrogen-Erα Pathway And Promoting PR Expression
·doi:10.21203/rs.3.rs-1228028/v1

Abstract Background: Endometriosis (EMS), an estrogen-dependent disease, is characterized by dysregulated inflammation and increased estrogen in ectopic lesions. However, the crosstalk and pathogenic mechanism of inflammation and estrogen h…

article 2022
SCM-198 Prevents Endometriosis by Reversing Low Autophagy of Endometrial Stromal Cell via Balancing ERα and PR Signals
Frontiers in endocrinology ·doi:10.3389/fendo.2022.858176

BACKGROUND: Endometriosis (EMS), an endocrine-related inflammatory disease, is characterized by estrogen and progesterone imbalance in ectopic lesions. However, its pathogenic mechanism has not been fully elucidated. While SCM-198 is the sy…

article 2017
Hydrogen sulfide prevents postoperative adhesion in a rat uterine horn model
·doi:10.1016/j.tjog.2016.09.004

OBJECTIVE: Abdominal adhesions are primarily severe postoperative complications that can cause gynecological problems such as infertility and chronic pelvic pain. Inflammatory mediators are significantly related to adhesion formation, and h…