Trippier PC

ORCID: 0000-0002-4947-5782 · 1 paper in corpus

2023

Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model.

Journal of medicinal chemistry ·doi:10.1021/acs.jmedchem.3c00732

Aldo-keto reductase 1C3 (AKR1C3) is overexpressed in castration-resistant prostate cancer where it acts to drive proliferation and aggressiveness by producing androgens. The reductive action of the enzyme leads to chemoresistance developmen…