Masanori Isobe

Endometriosis is a benign gynecological disorder characterized by the implantation of ectopic endometrial tissue outside the uterine cavity. Endometriotic lesions are commonly found in the pelvic cavity. Extra-pelvic endometriosis occurs mu…

INTRODUCTION: Dienogest (DNG) is widely used to manage endometriosis-associated pain; however, long-term data comparing low and standard doses are limited. Therefore, this study aimed to evaluate the efficacy and safety of 48-week DNG treat…

BACKGROUND: The treatment of endometriosis includes analgesics, hormone therapy, and surgery. Even after surgical removal of endometriotic lesions, the risk of recurrence remains high once the normal menstrual cycle resumes. Therefore, long…

BACKGROUND The treatment of endometriosis includes analgesics, hormone therapy, and surgery. Even after surgical removal of endometriotic lesions, the risk of recurrence remains high once the normal menstrual cycle resumes. Therefore, long…

ARID1A loss-of-function mutation accompanied by a loss of ARID1A protein expression is considered one of the most important driver events in endometriosis-associated ovarian cancer. Although our recent genomic study clarified that ARID1A lo…

Among various long-term complications after conization, complete cervical stenosis is rare (<1%) but significant. This condition is typically associated with secondary amenorrhea, cyclical lower abdominal pain, and hematometra during menstr…

Müllerian duct anomalies are known to cause infertility and reproductive problems. The true incidence of such abnormalities is not well defined. The most widely accepted method of classification for a Müllerian duct anomaly is the American …

Among various long-term complications after previous myomectomy, increasing risk of uterine rupture or dehiscence during pregnancy, and in particular during labor, has been widely recognized. In contrast, the world literature includes no ca…

Objective: To determine the risk factors which influence the recurrence of endometriomas after laparotomy or laparoscopic surgery.Design: Between 2000 and 2007, 98 patients who had endometrial cysts were treated by laparotomy or laparoscopi…