Katie M. O’Brien

Uterine fibroids and endometriosis may be associated with an increased risk of ovarian cancer. Less is known about the role of hysterectomy in these associations. We estimated the independent and joint associations of hysterectomy, fibroids…

BACKGROUND: Fibroids and endometriosis are sex hormone-mediated and exhibit cancer-like behavior. Breast cancer may be more common in women who have had these conditions, but the literature is conflicting and does not always address factors…

AbstractBackground:Fibroids and endometriosis are sex hormone–mediated and exhibit cancer-like behavior. Breast cancer may be more common in women who have had these conditions, but the literature is conflicting and does not always address …

AbstractBackground:Fibroids and endometriosis are sex hormone–mediated and exhibit cancer-like behavior. Breast cancer may be more common in women who have had these conditions, but the literature is conflicting and does not always address …

Histogram demonstrating the distribution of the age of diagnosis of both endometriosis and fibroids in the Sister Study cohort.

Histogram demonstrating the distribution of the age of diagnosis of both endometriosis and fibroids in the Sister Study cohort.

Results from logistic regression model among breast cancer cases assessing the relationship between history of fibroids or endometriosis and breast cancer subtype (ER+ versus ER-, PR+ versus PR-, HER2+ versus HER2- and triple-negative vs. n…

Results from logistic regression model among breast cancer cases assessing the relationship between history of fibroids or endometriosis and breast cancer subtype (ER+ versus ER-, PR+ versus PR-, HER2+ versus HER2- and triple-negative vs. n…

Association between fibroids diagnosed before age 35 (+/- uterine surgery) and breast cancer incidence, stratified by menopause status, using Cox proportional hazards models

Association between fibroids diagnosed before age 35 (+/- uterine surgery) and breast cancer incidence, stratified by menopause status, using Cox proportional hazards models

Association between endometriosis diagnosed before age 35 (+/- uterine surgery) and breast cancer overall and stratified by menopause status using Cox proportional hazards model

Association between endometriosis diagnosed before age 35 (+/- uterine surgery) and breast cancer overall and stratified by menopause status using Cox proportional hazards model

Association between fibroids or endometriosis (+\- surgical status) and hormone receptor subtype among breast cancer cases using logistic regression models

Association between fibroids or endometriosis (+\- surgical status) and hormone receptor subtype among breast cancer cases using logistic regression models

Association between fibroids and hormone receptor status among only Black / African American breast cancer cases

Association between fibroids and hormone receptor status among only Black / African American breast cancer cases

Association between fibroids and hormone receptor status among only Non- Black / African American breast cancer cases

Association between fibroids and hormone receptor status among only Non- Black / African American breast cancer cases

Association between fibroids and triple negative subtype among cases, stratified by race/ethnicity using logistic regression models

Association between fibroids and triple negative subtype among cases, stratified by race/ethnicity using logistic regression models

Association between endometriosis and triple negative subtype among cases stratified by race/ethnicity, using logistic regression models

Association between endometriosis and triple negative subtype among cases stratified by race/ethnicity, using logistic regression models

BACKGROUND: Gynecologic surgery is hypothesized to reduce risk of breast cancer; however, associations may be modified by subsequent hormone use. Our objective was to examine the association between gynecologic surgery and breast cancer inc…

PURPOSE: Frequent aspirin use has been associated with reduced ovarian cancer risk, but no study has comprehensively assessed for effect modification. We leveraged harmonized, individual-level data from 17 studies to examine the association…

BACKGROUND: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites. METHODS…