Sherr DH

ORCID: 0000-0003-3353-0553 · 3 papers in corpus
review 2025
The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation.
Nature reviews. Drug discovery ·doi:10.1038/s41573-025-01172-x

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor originally identified as the target mediating the toxic effects of environmental pollutants including polycyclic aromatic hydrocarbons (PAHs), polychlorinated bi…

review 2009
Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor
Biochemical pharmacology ·doi:10.1016/j.bcp.2008.09.016

The AHR is well known for regulating responses to an array of environmental chemicals. A growing body of evidence supports the hypothesis that the AHR also plays perhaps an even more important role in modulating critical aspects of cell fun…

lab-animal 2009
The active form of human aryl hydrocarbon receptor (AHR) repressor lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible factor
Molecular and cellular biology ·doi:10.1128/mcb.00206-09

The aryl hydrocarbon receptor (AHR) repressor (AHRR) inhibits AHR-mediated transcription and has been associated with reproductive dysfunction and tumorigenesis in humans. Previous studies have characterized the repressor function of AHRRs …