Zhang Q

ABSTRACT: This study aimed to investigate whether an early LH surge during controlled ovarian stimulation (COS) affects pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART) a…

Pelvic inflammatory disease (PID), a prevalent gynecological ailment compromising women's health, demonstrates established risk mitigation from dietary trace minerals. However, iron's role in PID pathogenesis remains unestablished. The Nati…

BACKGROUND: The adverse impacts of homeostasis disturbance of plasma trace elements on female reproduction, including premature ovarian insufficiency (POI), have received increasing attention recently, yet limited evidence has been reported…

A tipping point signals the shift from a stable phase to a malignant state in cervical cancer progression. Identifying this transition is essential for early intervention, yet traditional biomarkers based on differential expression or undir…

OBJECTIVE: To investigate the expression pattern, diagnostic value, and molecular mechanism of CCAAT/enhancer-binding protein delta (CEBPD) in uterine leiomyoma (ULM)-associated fibrosis, and to identify novel diagnostic biomarkers and ther…

OBJECTIVE: Current studies on adverse pregnancy outcomes in polycystic ovary syndrome (PCOS) have primarily focused on metabolic and endocrine abnormalities, whereas systematic investigations addressing live birth outcomes and coagulation d…

OBJECTIVE: To compare the clinical efficacy of letrozole-induced ovulation cycles, natural cycles, and Hormonal Replacement Therapy cycle in frozen embryo transfer (FET), and to investigate the effects of different endometrial preparation p…

BACKGROUND: Postmenopausal women are at elevated risk for carotid atherosclerosis due to estrogen decline, yet existing prediction models do not incorporate genetic markers. This study aimed to develop and validate a risk prediction model c…

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profi…

INTRODUCTION: Diminished ovarian reserve (DOR) is known to reduce the likelihood of achieving pregnancy or live births in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Acupuncture maybe effective for DOR, but current…

RESEARCH QUESTION: What is the impact of focal adenomyosis on IVF/iICSI outcomes, and what is the optimal protocol for these patients? DESIGN: This retrospective study screened 66,711 first IVF/ICSI cycles and identified 598 women with foc…

BACKGROUND: In this study, we aimed to explore the effect of the timing of surgical management of hydrosalpinx on in vitro fertilization/intracytoplasmic single-sperm injection (IVF/ICSI) pregnancy outcomes in patients with tubal factor inf…

BACKGROUND: Embryo implantation failure and early pregnancy loss remain significant challenges in assisted reproductive technology (ART). Lipid peroxidation is known to be involved in reproductive physiology. However, its role during the im…

Adult endometrial glands undergo cyclic regeneration and development during the menstrual cycle. Their secretions are vital for endometrial functions and early pregnancy, yet the mechanisms controlling gland development are not well underst…

Endometriosis diagnosis is often limited by the resolution of conventional imaging techniques (ultrasound/non-targeted MRI) as well as the invasiveness and recurrence risks associated with laparoscopy. To overcome these challenges, we devel…

This study employed a multi-omics Mendelian randomization (MR) framework to identify exosome-related genes potentially associated with adenomyosis risk. We integrated adenomyosis Genome-Wide Association Study data with blood-based methylati…

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential reproductive toxicity, yet their profiles in follicular fluid and impacts on human fertility remain unclear. Given the importance of diet as…

BACKGROUNDS: Abnormal cleavage (ABNCL) in early human embryos is a frequent phenomenon associated with impaired developmental competence and reduced reproductive potential. However, the clinical determinants of ABNCL and its subtypes remain…

Dyslipidaemia is related to endometriosis, but it is not known which lipid component is most relevant, and whether the observed correlation reflects the causal relationship. The relationship between triglycerides (TG) and endometriosis is s…

Chronic pelvic pain is a common and multifactorial clinical syndrome that markedly impairs quality of life in both men and women. Superior hypogastric plexus block (SHGPB) is an effective minimally invasive treatment. The sacral notch appro…

BACKGROUND: Premature ovarian insufficiency (POI) significantly impairs female fertility and poses substantial health risks; however, its pathogenesis is incompletely understood, and effective therapeutic interventions are limited. Although…

Biomarkers play a pivotal role in contemporary medical research, particularly in the early diagnosis of diseases and personalized treatment. Although previous studies have systematically reviewed markers across various disease domains, an i…

BACKGROUND: The ovary is a vital and dynamic reproductive organ. Ovarian tissue cryopreservation (OTC) plays a vital role in preserving female fertility. However, the cellular subtypes most susceptible to cryoinjury and the molecular mechan…

BACKGROUND: Endometriosis is a prevalent estrogen-dependent inflammatory disorder that compromises women's quality of life and fertility through chronic pelvic pain, inflammation, and reproductive dysfunction. Current clinical management re…

BACKGROUND: Endometrial receptivity in hormone replacement therapy-frozen embryo transfer (HRT-FET) cycles depends on a precisely coordinated estradiol-progesterone environment. An imbalance between estradiol (E2) and progesterone (P) befor…