Tuckey RC

ORCID: 0000-0002-5022-4729 · 1 paper in corpus · active 2020
2020
Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.
Genes and immunity ·doi:10.1038/s41435-020-0096-6

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone.…