Shah SP

No ORCID on file · 9 papers in corpus · active 2010-2024

Study types

  • article 3
  • other 1

Condition tags

  • endometriosis 4
2024
Sensitivity Analyses of a Scoring System for a Contraception Decision Aid.
AMIA ... Annual Symposium proceedings. AMIA Symposium

We conducted formal analyses of a scoring system for a contraception decision aid to support transgender and gender-nonconforming (TGNC) assigned female at birth (AFAB) individuals. For this purpose, we developed a methodology framework to …

2019
Molecular profiling and molecular classification of endometrioid ovarian carcinomas.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2019.07.012

ObjectiveEndometrioid ovarian carcinomas (EOCs) comprise 5-10% of all ovarian cancers and commonly co-occur with synchronous endometrioid endometrial cancer (EEC). We sought to examine the molecular characteristics of pure EOCs in patients …

article 2017
LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers
Gynecologic oncology ·doi:10.1016/j.ygyno.2017.09.032

ObjectiveEndometrioid (ENOC) and clear cell ovarian carcinoma (CCOC) share a common precursor lesion, endometriosis, hence the designation endometriosis associated ovarian cancers (EAOC). Long interspersed nuclear element 1 (LINE-1 or L1), …

article 2015
Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden
The Journal of Pathology ·doi:10.1002/path.4516

Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole-genome shotgun sequencing of seven clear cell ovarian carcinomas (CCC) and targeted seq…

other 2014
Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.2013.107

Ovarian endometrioid carcinomas and endometrial endometrioid carcinomas share many histological and molecular alterations. These similarities are likely due to a common endometrial epithelial precursor cell of origin, with most ovarian endo…

2013
Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.
The Journal of Pathology ·doi:10.1002/path.4230

High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to the emergence of treatment-resistant subclones. We sought to measure the degree of genomic diversity within primary, untreated HGSCs to examine th…

2013
Type-specific cell line models for type-specific ovarian cancer research.
PloS one ·doi:10.1371/journal.pone.0072162

BackgroundOVARIAN CARCINOMAS CONSIST OF AT LEAST FIVE DISTINCT DISEASES: high-grade serous, low-grade serous, clear cell, endometrioid, and mucinous. Biomarker and molecular characterization may represent a more biologically relevant basis …

2012
14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1115528109

14-3-3 proteins are ubiquitously expressed regulators of various cellular functions, including proliferation, metabolism, and differentiation, and altered 14-3-3 expression is associated with development and progression of cancer. We report…

article 2010
ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
The New England journal of medicine ·doi:10.1056/nejmoa1008433

BACKGROUND: Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS: We sequenced the whole transcriptomes of 18 ovarian clear-ce…