Jie Xu

OBJECTIVE: To apply an MR-PheWAS to infer causality between NSW and multiple health outcomes. METHODS: This study used MR-PheWAS to assess the causal effects of NSW on 18,115 health traits, applying IVW, MR-Egger, Wald ratio, and sensitivi…

Alzheimer’s Disease (AD) is a complex neurodegenerative disorder strongly influenced by sex differences, with women comprising nearly two-thirds of cases. However, sex-specific progression patterns remain underexplored due to unclear clinic…

ABSTRACT Federated learning is a technique for training predictive models without sharing patient-level data, thus maintaining data security while allowing inter-institutional collaboration. We used federated learning to predict acute kidne…

This study was conducted to define the underlying molecular mechanism of tripartite motif (TRIM) 59-induced invasion of ectopic endometrial stromal cells in endometriosis. Primary endometriosis ectopic endometrial stromal cells and normal e…

Abstract: Intrauterine adhesions (IUA) frequently occur after infectious or mechanical injury to the endometrium, which may lead to infertility and/or pregnancy complications. There are few effective treatments due to the complex function o…

Identification of target molecules specific for angiogenic vascular endothelial cells (VEC), the inner layer of pathological neovasculature, is critical for discovery and development of neovascular-targeting therapy for angiogenesis-depende…

The human immunodeficiency virus type 1 (HIV-1)–specific immune responses of patients with the HLA-B*57/5801 al-leles who spontaneously control viral replication serve as an important model for T cell–based HIV-1 vaccines. Deter-mining the …

Uterine leiomyoma (UL) is an estrogen-responsive benign tumor in the female reproductive system and the main risk of hysterectomy for women. However, gene polymorphism of estrogen-metabolizing enzymes may lead to the different susceptibilit…