Yuan Gu

ORCID: 0000-0003-1401-6233 · 5 papers in corpus
2022
Replacement in angiogenesis research: Studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches.
Frontiers in physiology ·doi:10.3389/fphys.2022.981161

Angiogenesis, the development of new blood vessels from pre-existing ones, is an essential process determining numerous physiological and pathological conditions. Accordingly, there is a high demand for research approaches allowing the inve…

article 2021
Differences in growth and vascularization of ectopic menstrual and non-menstrual endometrial tissue in mouse models of endometriosis
Human Reproduction ·doi:10.1093/humrep/deab139

STUDY QUESTION: Is there a difference in the growth and vascularization between murine endometriotic lesions originating from menstrual or non-menstrual endometrial fragments? SUMMARY ANSWER: Endometriotic lesions developing from menstrual …

2021
Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8.
Angiogenesis ·doi:10.1007/s10456-021-09772-y

Angiogenesis crucially contributes to various diseases, such as cancer and diabetic retinopathy. Hence, anti-angiogenic therapy is considered as a powerful strategy against these diseases. Previous studies reported that the acyclic monoterp…

article 2017
Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions
British journal of pharmacology ·doi:10.1111/bph.13874

BACKGROUND AND PURPOSE: Telmisartan suppresses the development of endometriotic lesions. However, the drug also up-regulates the expression of COX-2, which has been suggested to promote the progression of endometriosis. Accordingly, in the …

article 2014
Combined blockade of angiotensin II type 1 receptor and activation of peroxisome proliferator-activated receptor-  by telmisartan effectively inhibits vascularization and growth of murine endometriosis-like lesions
Human Reproduction ·doi:10.1093/humrep/deu035

STUDY QUESTION: Is telmisartan effective in the treatment of endometriosis? SUMMARY ANSWER: Combined blockade of angiotensin II type 1 receptor (AT1R) and activation of peroxisome proliferator-activated receptor (PPAR)-γ by telmisartan inhi…