Nicole Donnellan

Endometriosis (EM) is a debilitating disease involving the growth of endometrial glands and stroma outside the uterus. To further our understanding of epigenomic dysregulation in EM and search for disease biomarkers, we performed a comprehe…

Objective: The objective of this study is to determine whether patients who are diagnosed with ovarian endometrioma(s) on imaging undergo fewer total surgeries for treatment of their endometrioma and endometriosis if the initial surgery is …

INTRODUCTION: Definitive surgical management of severe endometriosis involves excision with hysterectomy and bilateral salpingo-oophorectomy (BSO). Women who are less than 50 years old at the time of BSO have an increased morbidity, includi…

Supplementary figures and table

AbstractPurpose: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian …

AbstractPurpose: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian …

AbstractOvarian clear cell carcinoma (OCCC) is a deadly and treatment-resistant cancer, which arises within the unique microenvironment of endometriosis. In this study, we identified a subset of endometriosis-derived mesenchymal stem cells …

AbstractOvarian clear cell carcinoma (OCCC) is a deadly and treatment-resistant cancer, which arises within the unique microenvironment of endometriosis. In this study, we identified a subset of endometriosis-derived mesenchymal stem cells …

AbstractPurpose: Endometriosis, a largely benign, chronic inflammatory disease, is an independent risk factor for endometrioid and clear cell epithelial ovarian tumors. We aimed to identify plasma miRNAs that can be used to differentiate pa…

AbstractPurpose: Endometriosis, a largely benign, chronic inflammatory disease, is an independent risk factor for endometrioid and clear cell epithelial ovarian tumors. We aimed to identify plasma miRNAs that can be used to differentiate pa…

Supplementary figures and table

Supplementary figures and table

PDF file - 488K, Supplementary Figure 1: Experimental design. Supplementary Figure 2. Reliability of RNA extraction and reproducibility of RTqPCR techniques. Supplementary Figure 3. Reliability of RT-qPCR assays. Supplementary Figure 4. miR…

PDF file - 488K, Supplementary Figure 1: Experimental design. Supplementary Figure 2. Reliability of RNA extraction and reproducibility of RTqPCR techniques. Supplementary Figure 3. Reliability of RT-qPCR assays. Supplementary Figure 4. miR…

Supplementary Materials and Methods

Supplementary Materials and Methods

PDF file - 36K, Supplementary Table 1. Demographic and clinical characteristics of the study cohort. Supplementary Table 2. List of the 24 miRNAs identified by genome-wide plasma miRNA expression profiling from healthy controls (n=6), endom…

PDF file - 36K, Supplementary Table 1. Demographic and clinical characteristics of the study cohort. Supplementary Table 2. List of the 24 miRNAs identified by genome-wide plasma miRNA expression profiling from healthy controls (n=6), endom…

Suppl Fig S1. Venn diagram of DE genes from 3 group comparisons

Suppl Fig S1. Venn diagram of DE genes from 3 group comparisons

Suppl Fig S2. Kras and Pten pathways in relationship to complement gene expression

Suppl Fig S2. Kras and Pten pathways in relationship to complement gene expression

Suppl Fig S3. Antibody-mediated, complement-induced cytotoxicity