Li L

To evaluate the impact of hepatitis B virus (HBV) carrier status on oocyte quality, embryonic development, and pregnancy outcomes in women with varying ovarian reserve undergoing in vitro fertilization and embryo transfer (IVF-ET). This ret…

OBJECTIVE: This retrospective cohort study compares perioperative outcomes of reduced Trendelenburg positioning (≤ 20°) versus conventional steep angles (≥ 30°) in gasless vNOTES for benign gynecologic conditions. METHODS: Of 102 enrolled p…

OBJECTIVE: Endometrial cancer (EC) is a common gynecologic malignancy globally, but the role of the intratumoral microbiome remains poorly defined. While microbial dysbiosis is increasingly linked to cancer, the composition, function, and c…

BACKGROUND: Cervical squamous cell carcinoma (CSCC) exhibits profound spatial heterogeneity in evolutionary trajectories across distinct tumour foci, yet the underlying mechanisms remain poorly understood. METHODS: In this study, we perfor…

This study aimed to enhance preoperative diagnostic accuracy for early ovarian cancer (EOC) by constructing and validating an interpretable predictive model integrating serological markers with O-RADS ultrasound risk stratification. A total…

OBJECTIVE: Per- and polyfluoroalkyl substances (PFAS) are omnipresent, persistent contaminants associated with rising ovarian cancer incidence; however, the molecular circuitry linking PFAS to ovarian tumorigenesis remains obscure. METHODS…

BACKGROUND: Salpingitis is a leading cause of female infertility and ectopic pregnancy worldwide. Despite advances in reproductive medicine, its early diagnosis and effective prevention of long-term sequelae remain challenging due to its of…

Endometrial receptivity within the window of implantation (WOI) has been increasingly recognized as an independent determinant of pregnancy outcome in assisted reproduction. Persistent recurrent implantation failure (RIF) is observed in a s…

INTRODUCTION: NR5A1 variants are among the most frequent monogenic causes of disorders of sex development (DSD). However, genotype-phenotype correlations remain unclear, and oligogenic contributions to variability are underexplored in non-c…

BACKGROUND: Vitamin D deficiency is a global public health concern, and women of reproductive age represent a particularly vulnerable population. Accurate measurement of serum 25-hydroxyvitamin D [25(OH)D] is therefore essential for reliabl…

Serum and plasma are the most widely used matrices in metabolomics and human biomonitoring studies; however, the optimal matrix for integrated non-targeted analysis (NTA) workflows combining metabolomics and exposomics has not been systemat…

Background: Polydatin has shown anti-inflammatory, antioxidant, and cytoprotective effects in preclinical studies. Its development is limited by low oral bioavailability, extensive metabolism, and poorly defined tissue exposure. Objectives:…

Spinal cord injury (SCI) is a serious neurological system disease. After SCI, a series of cascade reactions can cause irreversible damage, with a high disability rate and mortality rate. The complexity of the pathological mechanism of SCI l…

Infertility affects ~1 in 6 people of reproductive age and remains difficult to treat because causes are heterogeneous and diagnostics are incomplete. Recent evidence reframes the female reproductive tract as a low-biomass but biologically …

PURPOSE: Precocious puberty (PP) is a pediatric endocrine disorder. Bisphenol A (BPA) is an endocrine disruptor. This study aimed to computationally investigate BPA-associated PP targets and mechanisms via network toxicology and molecular d…

PURPOSE: Accurate prognostic prediction remains a significant challenge in the management of low-grade serous ovarian cancer (LGSOC), a rare and molecularly distinct histologic subtype. This study aimed to develop a prediction model visuali…

Fisetin, a flavonoid widely present in natural plants, exhibits diverse pharmacological activities including antioxidant, anti-inflammatory, anti-apoptotic, and anti-aging effects. Its protective roles within the mammalian reproductive syst…

Premature ovarian failure (POF) and insufficiency induced by cisplatin are common complications associated with gynecological diseases. This study aims to investigate the role of N6-methyladenosine (m6A) methyltransferase METTL16 in cisplat…

G protein-coupled receptors (GPCRs) serve as central hubs in tumor signal transduction and microenvironment regulation. However, their therapeutic exploitation is confounded by a fundamental complexity: GPCR functions are exquisitely contex…

N 6-methyladenosine (m6A) and N6, 2'-O-dimethyladenosine (m6Am) are two RNA modifications that play essential roles in diverse RNA metabolic processes and functions. Despite their importance, the dynamic landscapes and regulatory patterns o…

BACKGROUND: Women with advanced maternal age (AMA) face a significant decline in embryo euploidy rates, leading to reduced fertility and increased risks of adverse pregnancy outcomes. While preimplantation genetic testing for aneuploidy (PG…

The study explored the mechanism of Dan'e-fukang soft extract in treating endometriosis (EMs) through network pharmacology. The main active ingredients of Dan'e-fukang soft extract were analyzed based on the traditional Chinese medicine sys…

Abstract Background The current study investigated the correlation between the uterine corpus flexion angle (UCFA) and the severity of endometriosis, evaluated its clinical utility as a novel objective sonographic parameter, and provided …

ABSTRACT: Endometriosis is a disease where cells similar to those of the uterine lining grow outside of the uterus, embedding into tissues and organs in the abdominal cavity, forming lesions and causing pain and infertility. Previous studie…

OBJECTIVE: This work aimed to evaluate the clinical value of serumanti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and transvaginal ultrasound (TVU) parameters in the diagnosis of ovarian reserve f…