Shridhar V

No ORCID on file · 6 papers in corpus · active 2013-2020
2020
Combining copy number, methylation markers, and mutations as a panel for endometrial cancer detection via intravaginal tampon collection.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2019.11.028

ObjectiveWe aimed to assess whether endometrial cancer (EC) can be detected in shed DNA collected with vaginal tampon by analyzing copy number, methylation markers, and mutations.MethodsTampons were collected prior to hysterectomy from 38 E…

2015
Detection of endometrial cancer via molecular analysis of DNA collected with vaginal tampons.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2015.01.552

ObjectiveWe demonstrate the feasibility of detecting EC by combining minimally-invasive specimen collection techniques with sensitive molecular testing.MethodsPrior to hysterectomy for EC or benign indications, women collected vaginal pool …

2015
TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer.
Nucleic acids research ·doi:10.1093/nar/gkv111

To determine early somatic changes in high-grade serous ovarian cancer (HGSOC), we performed whole genome sequencing on a rare collection of 16 low stage HGSOCs. The majority showed extensive structural alterations (one had an ultramutated …

2014
Methylation of leukocyte DNA and ovarian cancer: relationships with disease status and outcome.
BMC medical genomics ·doi:10.1186/1755-8794-7-21

BackgroundGenome-wide interrogation of DNA methylation (DNAm) in blood-derived leukocytes has become feasible with the advent of CpG genotyping arrays. In epithelial ovarian cancer (EOC), one report found substantial DNAm differences betwee…

2013
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.
Nature communications ·doi:10.1038/ncomms2629

HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovaria…

2013
Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel.
Human molecular genetics ·doi:10.1093/hmg/ddt160

Ovarian cancer remains the leading cause of death in women with gynecologic malignancies, despite surgical advances and the development of more effective chemotherapeutics. As increasing evidence indicates that clear-cell ovarian cancer may…